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KMID : 1143420200130171130
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Public Health Weekly Report
2020 Volume.13 No. 17 p.1130 ~ p.1147
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An Analysis of Active Tuberculosis Progress in the National Latent Tuberculosis Infection Cohort
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Kim Hyung-Wook
Min Jin-Soo
Kim Ju-Sang
Kim Ga-Hee
Chun Chae-Min
In Hye-Kyung
Shim Eun-Hye
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Abstract
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To drastically reduce the incidence of tuberculosis (TB) in Korea, the national latent tuberculosis screening project was
implemented since 2017. The project was focused on group facility workers, high school first grade students, individuals
subject to the military draft physical examination, and inmates in correctional facilities. In this project, among the individuals who were latent TB infection positive, the treatment start rate was 35.23% and the treatment completion rate was
29.16%. Only 41.79% of the individuals who were TB positive visited a medical institution or health center after diagnosis of
latent TB infection and 84.30% of visitors started treatment. According to the results of tracking the occurrence of active
TB in patients with latent TB, Interferon-Gamma Releasing Assay (IGRA) positive among group facility workers had an active TB incidence rate 16.3 times higher than TB negative individuals even if they had not had clear contact with TB, and showed a preventive effect of 82% when they completed latent TB treatment. Most of the cohort targets in this project were people of working age, and despite domestic and international studies that indicated increases in the risk of TB, the effect of comorbidities was not clearly documented in this study.
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KEYWORD
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Latent Tuberculosis Infection, Treatment Effect, Interferon-Gamma Releasing Assay (IGRA), Active Tuberculosis, Group facility worker
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